It refers to the total amount of immunoglobulins E. IgE is an acronym for immunoglobulins E. IgE is produced by cells, which we call plasma cells. IgE are an important part of the immune response. They participate in the defense of the body against parasites. IgE also play an important role in Type I hypersensitivity, which we encounter in asthma, allergic rhinitis, food allergy, atopic dermatitis. IgE also play an important role in severe allergic reactions such as anaphylactic reaction.